Assay Detail
Binding
CHEMBL1686909
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Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.85 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 9.50 |
| CHEMBL1209708 | — | — | 1 | 9.10 |
| CHEMBL188 | WIN-552122 | — | 1 | 8.60 |
| CHEMBL1682272 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL1209708 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL188 | WIN-552122 | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1682272 | — | Ki | = | 6.31 | nM | 8.20 |