Assay Detail
Binding
CHEMBL1686964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human V1b receptor expressed in CHO cells co-expressing VIP-luciferase by whole cell binding assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.82 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684573 | — | — | 1 | 8.52 |
| CHEMBL1684561 | — | — | 1 | 8.40 |
| CHEMBL1684562 | — | — | 1 | 8.30 |
| CHEMBL1684574 | — | — | 1 | 8.22 |
| CHEMBL1684408 | — | — | 1 | 7.82 |
| CHEMBL1684571 | — | — | 1 | 7.77 |
| CHEMBL1684560 | — | — | 1 | 7.58 |
| CHEMBL1684409 | — | — | 1 | 7.52 |
| CHEMBL1684559 | — | — | 1 | 7.47 |
| CHEMBL1684557 | — | — | 1 | 7.38 |
| CHEMBL1684572 | — | — | 1 | 7.34 |
| CHEMBL1684570 | — | — | 1 | 7.31 |
| CHEMBL1684558 | — | — | 1 | 7.23 |
| CHEMBL1684569 | — | — | 1 | 7.14 |
| CHEMBL1684555 | — | — | 1 | 7.07 |
| CHEMBL1684410 | — | — | 1 | 6.95 |
| CHEMBL1684556 | — | — | 1 | 6.91 |
| CHEMBL1684407 | — | — | 1 | 6.90 |
| CHEMBL1684567 | — | — | 1 | 6.82 |
| CHEMBL1684568 | — | — | 1 | 6.71 |
| CHEMBL1684405 | — | — | 1 | 6.60 |
| CHEMBL1684553 | — | — | 1 | 6.49 |
| CHEMBL1684548 | — | — | 1 | 6.48 |
| CHEMBL1684406 | — | — | 1 | 6.44 |
| CHEMBL1684551 | — | — | 1 | 6.41 |
| CHEMBL1684549 | — | — | 1 | 6.33 |
| CHEMBL1684550 | — | — | 1 | 6.19 |
| CHEMBL1684404 | — | — | 1 | 6.10 |
| CHEMBL1684403 | — | — | 1 | 5.99 |
| CHEMBL1684546 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684573 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1684561 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1684562 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1684574 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1684408 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1684571 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1684560 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1684409 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1684559 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1684557 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1684572 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1684570 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1684558 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1684569 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1684555 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1684410 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1684556 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL1684407 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1684567 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL1684568 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL1684405 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1684553 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL1684548 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL1684406 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL1684551 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL1684549 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1684550 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL1684404 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1684403 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1684546 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1684402 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1684566 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL1684552 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1684565 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1684547 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1684554 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL1684564 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1684563 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1684575 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1684576 | — | IC50 | > | 20000.0 | nM | - |