Assay Detail
Functional
CHEMBL1687076
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.59 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.00 |
| CHEMBL1684589 | ASIATICOSIDE G | — | 1 | 4.45 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.18 |
| CHEMBL233930 | ASTRAGALIN | — | 1 | 4.17 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 4.13 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 4.12 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.09 |
| CHEMBL1789965 | ASIATICOSIDE | — | 1 | 4.07 |
| CHEMBL500352 | QUADRANOSIDE IV | — | 1 | 4.06 |
| CHEMBL1684591 | ASIATICOSIDE F | — | 1 | - |
| CHEMBL1684592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1684589 | ASIATICOSIDE G | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL50 | QUERCETIN | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL233930 | ASTRAGALIN | IC50 | = | 67100.0 | nM | 4.17 |
| CHEMBL404313 | ASIATIC ACID | IC50 | = | 74800.0 | nM | 4.13 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 80300.0 | nM | 4.09 |
| CHEMBL1789965 | ASIATICOSIDE | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL500352 | QUADRANOSIDE IV | IC50 | = | 86400.0 | nM | 4.06 |
| CHEMBL1684591 | ASIATICOSIDE F | IC50 | > | 100000.0 | nM | - |
| CHEMBL1684592 | — | IC50 | > | 100000.0 | nM | - |