Assay Detail
Binding
CHEMBL1687151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17,20 lyase activity in human
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.41 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682900 | — | — | 3 | 7.82 |
| CHEMBL1682893 | — | — | 1 | 7.80 |
| CHEMBL1682903 | — | — | 1 | 7.72 |
| CHEMBL1682904 | — | — | 1 | 7.72 |
| CHEMBL1682901 | — | — | 1 | 7.66 |
| CHEMBL1682891 | — | — | 1 | 7.62 |
| CHEMBL1682887 | — | — | 1 | 7.55 |
| CHEMBL1682888 | — | — | 1 | 7.55 |
| CHEMBL1682892 | — | — | 1 | 7.52 |
| CHEMBL1682890 | — | — | 1 | 7.44 |
| CHEMBL1682902 | — | — | 1 | 7.44 |
| CHEMBL1682895 | — | — | 1 | 7.42 |
| CHEMBL1682889 | — | — | 1 | 7.41 |
| CHEMBL1682899 | — | — | 1 | 7.41 |
| CHEMBL1682894 | — | — | 1 | 7.34 |
| CHEMBL1682896 | — | — | 1 | 7.12 |
| CHEMBL1682898 | — | — | 1 | 6.80 |
| CHEMBL1682897 | — | — | 1 | 6.70 |
| CHEMBL1682905 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682900 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1682893 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1682900 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1682903 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1682904 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1682901 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1682891 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1682887 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1682888 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1682892 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1682890 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1682902 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1682895 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1682889 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1682899 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1682894 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1682900 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1682896 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1682898 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1682897 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1682905 | — | IC50 | = | 270.0 | nM | 6.57 |