Assay Detail
Functional
CHEMBL1687233
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Cytotoxicity against human A375P cells after 2 days by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A375P |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.25 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684614 | — | — | 1 | 5.62 |
| CHEMBL1684615 | — | — | 1 | 5.58 |
| CHEMBL1684607 | — | — | 1 | 5.58 |
| CHEMBL1684606 | — | — | 1 | 5.55 |
| CHEMBL1684594 | — | — | 1 | 5.52 |
| CHEMBL1684605 | — | — | 1 | 5.48 |
| CHEMBL1684595 | — | — | 1 | 5.47 |
| CHEMBL1684596 | — | — | 1 | 5.43 |
| CHEMBL1684593 | — | — | 1 | 5.41 |
| CHEMBL1684613 | — | — | 1 | 5.35 |
| CHEMBL1684616 | — | — | 1 | 5.28 |
| CHEMBL1684609 | — | — | 1 | 5.13 |
| CHEMBL1684604 | — | — | 1 | 5.12 |
| CHEMBL1684612 | — | — | 1 | 5.07 |
| CHEMBL1684603 | — | — | 1 | 5.04 |
| CHEMBL1684601 | — | — | 1 | 4.71 |
| CHEMBL1684610 | — | — | 1 | 4.65 |
| CHEMBL1684602 | — | — | 1 | 4.46 |
| CHEMBL533658 | — | — | 1 | - |
| CHEMBL1684600 | — | — | 1 | - |
| CHEMBL1684599 | — | — | 1 | - |
| CHEMBL1684608 | — | — | 1 | - |
| CHEMBL1684611 | — | — | 1 | - |
| CHEMBL1684598 | — | — | 1 | - |
| CHEMBL1684597 | — | — | 1 | - |
| CHEMBL1681818 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684614 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL1684615 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL1684607 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL1684606 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL1684594 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL1684605 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1684595 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL1684596 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL1684593 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1684613 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1684616 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL1684609 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL1684604 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL1684612 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL1684603 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1684601 | — | IC50 | = | 19390.0 | nM | 4.71 |
| CHEMBL1684610 | — | IC50 | = | 22510.0 | nM | 4.65 |
| CHEMBL1684602 | — | IC50 | = | 34880.0 | nM | 4.46 |
| CHEMBL533658 | — | IC50 | - | — | - | |
| CHEMBL1684600 | — | IC50 | - | — | - | |
| CHEMBL1684599 | — | IC50 | - | — | - | |
| CHEMBL1684608 | — | IC50 | - | — | - | |
| CHEMBL1684611 | — | IC50 | - | — | - | |
| CHEMBL1684598 | — | IC50 | - | — | - | |
| CHEMBL1684597 | — | IC50 | - | — | - | |
| CHEMBL1681818 | — | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |