Assay Detail
Functional
CHEMBL1687388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cholesterol synthesis in rat hepatic cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.17 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1685025 | — | — | 1 | 7.08 |
| CHEMBL1685029 | — | — | 1 | 6.77 |
| CHEMBL1685021 | — | — | 1 | 6.70 |
| CHEMBL1685018 | — | — | 1 | 6.64 |
| CHEMBL1684827 | — | — | 1 | 6.60 |
| CHEMBL1684835 | — | — | 1 | 6.57 |
| CHEMBL1685014 | — | — | 1 | 6.22 |
| CHEMBL1684829 | — | — | 1 | 6.05 |
| CHEMBL1685011 | — | — | 1 | 6.04 |
| CHEMBL1685022 | — | — | 1 | 5.89 |
| CHEMBL1684841 | — | — | 1 | 5.85 |
| CHEMBL1685028 | — | — | 1 | 5.82 |
| CHEMBL1685017 | — | — | 1 | 5.80 |
| CHEMBL1684832 | — | — | 1 | 5.80 |
| CHEMBL1684826 | — | — | 1 | 5.77 |
| CHEMBL1684833 | — | — | 1 | 5.70 |
| CHEMBL1684836 | — | — | 1 | 5.58 |
| CHEMBL1685010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1685025 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1685029 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1685021 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1685018 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1684827 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1684835 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1685014 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1684829 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1685011 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1685022 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1684841 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1685028 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1685017 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1684832 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1684826 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1684833 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1684836 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1685010 | — | IC50 | > | 10000.0 | nM | - |