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Assay Detail

CHEMBL1687447

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Binding
Inhibition of QPP
ChEMBL ↗
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dipeptidyl peptidase 2 (CHEMBL3976) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
Chen P, Caldwell CG, Ashton W, Wu JK, He H, Lyons KA, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2011) 21 : 1880 -1886
PubMed 21320777 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 75 4.60 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1682974 — — 1 6.16
CHEMBL25211 — — 1 5.93
CHEMBL1683107 — — 1 5.44
CHEMBL1683124 — — 1 5.32
CHEMBL1682985 — — 1 5.07
CHEMBL1682977 — — 1 5.02
CHEMBL1683093 — — 1 5.00
CHEMBL1683096 — — 1 4.96
CHEMBL1683137 — — 1 4.96
CHEMBL1683121 — — 1 4.96
CHEMBL1683125 — — 1 4.92
CHEMBL1683143 — — 1 4.89
CHEMBL1682984 — — 1 4.89
CHEMBL1683126 — — 1 4.85
CHEMBL1682982 — — 1 4.82
CHEMBL1683113 — — 1 4.80
CHEMBL1682983 — — 1 4.77
CHEMBL1683116 — — 1 4.77
CHEMBL1683111 — — 1 4.77
CHEMBL1681802 — — 1 4.75
CHEMBL1683105 — — 1 4.75
CHEMBL1683131 — — 1 4.72
CHEMBL1682979 — — 1 4.72
CHEMBL1682976 — — 1 4.70
CHEMBL1682981 — — 1 4.70
CHEMBL1682975 — — 1 4.70
CHEMBL1683109 — — 1 4.68
CHEMBL1683138 — — 1 4.66
CHEMBL1683145 — — 1 4.64
CHEMBL1682978 — — 1 4.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1682974 — IC50 = 690.0 nM 6.16
CHEMBL25211 — IC50 = 1180.0 nM 5.93
CHEMBL1683107 — IC50 = 3600.0 nM 5.44
CHEMBL1683124 — IC50 = 4800.0 nM 5.32
CHEMBL1682985 — IC50 = 8500.0 nM 5.07
CHEMBL1682977 — IC50 = 9600.0 nM 5.02
CHEMBL1683093 — IC50 = 10000.0 nM 5.00
CHEMBL1683096 — IC50 = 11000.0 nM 4.96
CHEMBL1683137 — IC50 = 11000.0 nM 4.96
CHEMBL1683121 — IC50 = 11000.0 nM 4.96
CHEMBL1683125 — IC50 = 12000.0 nM 4.92
CHEMBL1683143 — IC50 = 13000.0 nM 4.89
CHEMBL1682984 — IC50 = 13000.0 nM 4.89
CHEMBL1683126 — IC50 = 14000.0 nM 4.85
CHEMBL1682982 — IC50 = 15000.0 nM 4.82
CHEMBL1683113 — IC50 = 16000.0 nM 4.80
CHEMBL1682983 — IC50 = 17000.0 nM 4.77
CHEMBL1683116 — IC50 = 17000.0 nM 4.77
CHEMBL1683111 — IC50 = 17000.0 nM 4.77
CHEMBL1681802 — IC50 = 18000.0 nM 4.75
CHEMBL1683105 — IC50 = 18000.0 nM 4.75
CHEMBL1683131 — IC50 = 19000.0 nM 4.72
CHEMBL1682979 — IC50 = 19000.0 nM 4.72
CHEMBL1682975 — IC50 = 20000.0 nM 4.70
CHEMBL1682976 — IC50 = 20000.0 nM 4.70
CHEMBL1682981 — IC50 = 20000.0 nM 4.70
CHEMBL1683109 — IC50 = 21000.0 nM 4.68
CHEMBL1683138 — IC50 = 22000.0 nM 4.66
CHEMBL1683145 — IC50 = 23000.0 nM 4.64
CHEMBL1682978 — IC50 = 23000.0 nM 4.64
CHEMBL1683128 — IC50 = 23000.0 nM 4.64
CHEMBL1683127 — IC50 = 27000.0 nM 4.57
CHEMBL1683135 — IC50 = 28000.0 nM 4.55
CHEMBL1682980 — IC50 = 29000.0 nM 4.54
CHEMBL1683092 — IC50 = 29000.0 nM 4.54
CHEMBL1683139 — IC50 = 30000.0 nM 4.52
CHEMBL1683114 — IC50 = 31000.0 nM 4.51
CHEMBL1683108 — IC50 = 32000.0 nM 4.50
CHEMBL1683089 — IC50 = 34000.0 nM 4.47
CHEMBL1683133 — IC50 = 34000.0 nM 4.47
CHEMBL1683140 — IC50 = 35000.0 nM 4.46
CHEMBL1683090 — IC50 = 35000.0 nM 4.46
CHEMBL1683132 — IC50 = 37000.0 nM 4.43
CHEMBL1683134 — IC50 = 39000.0 nM 4.41
CHEMBL1683094 — IC50 = 40000.0 nM 4.40
CHEMBL1683141 — IC50 = 42000.0 nM 4.38
CHEMBL1683088 — IC50 = 43000.0 nM 4.37
CHEMBL1683142 — IC50 = 48000.0 nM 4.32
CHEMBL1683112 — IC50 = 51000.0 nM 4.29
CHEMBL1683136 — IC50 = 52000.0 nM 4.28