Assay Detail
Binding
CHEMBL1687517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 2008 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.50 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.90 |
| CHEMBL74898 | AYANIN | — | 1 | 4.30 |
| CHEMBL77966 | RETUSIN | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL74898 | AYANIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL77966 | RETUSIN | IC50 | = | 50000.0 | nM | 4.30 |