Assay Detail
Binding
CHEMBL1687572
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Inhibition of caspase 3 using Ac-DEVD-AFC fluorogenic substrate
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isatin 1,2,3-triazoles as potent inhibitors against caspase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456799 | — | — | 1 | 9.30 |
| CHEMBL1683316 | — | — | 1 | 8.05 |
| CHEMBL456798 | — | — | 1 | 7.78 |
| CHEMBL1683178 | — | — | 1 | 7.77 |
| CHEMBL1683176 | — | — | 1 | 7.75 |
| CHEMBL1683173 | — | — | 1 | 7.68 |
| CHEMBL1683175 | — | — | 1 | 7.68 |
| CHEMBL1683174 | — | — | 1 | 7.64 |
| CHEMBL1683179 | — | — | 1 | 7.52 |
| CHEMBL1683177 | — | — | 1 | 7.36 |
| CHEMBL62993 | — | — | 1 | 7.36 |
| CHEMBL1683185 | — | — | 1 | 7.16 |
| CHEMBL1683181 | — | — | 1 | 6.99 |
| CHEMBL60190 | — | — | 1 | 6.92 |
| CHEMBL1683182 | — | — | 1 | 6.87 |
| CHEMBL1683186 | — | — | 1 | 6.87 |
| CHEMBL1683317 | — | — | 1 | 6.68 |
| CHEMBL1683183 | — | — | 1 | 6.67 |
| CHEMBL1683180 | — | — | 1 | 6.61 |
| CHEMBL1683184 | — | — | 1 | 6.57 |
| CHEMBL118305 | 5-NITROISATIN | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456799 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1683316 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL456798 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL1683178 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1683176 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1683173 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1683175 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1683174 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1683179 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1683177 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL62993 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1683185 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1683181 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL60190 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1683182 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL1683186 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL1683317 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1683183 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1683180 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL1683184 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL118305 | 5-NITROISATIN | IC50 | = | 1000.0 | nM | 6.00 |