Assay Detail
Functional
CHEMBL1687606
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Antiproliferative activity against human DLD1 cells assessed as growth inhibition
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 9.04 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1683528 | — | — | 1 | 9.70 |
| CHEMBL1683529 | — | — | 1 | 9.57 |
| CHEMBL1683530 | — | — | 1 | 9.57 |
| CHEMBL1683523 | — | — | 1 | 9.44 |
| CHEMBL1683543 | — | — | 1 | 9.42 |
| CHEMBL1683525 | — | — | 1 | 9.36 |
| CHEMBL1683539 | — | — | 1 | 9.35 |
| CHEMBL1683538 | — | — | 1 | 9.33 |
| CHEMBL1683522 | — | — | 1 | 9.27 |
| CHEMBL1683532 | — | — | 1 | 9.17 |
| CHEMBL1683527 | — | — | 1 | 9.12 |
| CHEMBL1683534 | — | — | 1 | 9.11 |
| CHEMBL1683524 | — | — | 1 | 9.10 |
| CHEMBL1683537 | — | — | 1 | 9.08 |
| CHEMBL1683526 | — | — | 1 | 9.06 |
| CHEMBL1683535 | — | — | 1 | 8.98 |
| CHEMBL1683542 | — | — | 1 | 8.85 |
| CHEMBL1683540 | — | — | 1 | 8.84 |
| CHEMBL1683533 | — | — | 1 | 7.98 |
| CHEMBL1683536 | — | — | 1 | 7.76 |
| CHEMBL1683590 | ERIBULIN | 4.0 | 1 | 7.70 |
| CHEMBL1683531 | — | — | 1 | - |
| CHEMBL1683541 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1683528 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1683529 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1683530 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1683523 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL1683543 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1683525 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL1683539 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL1683538 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1683522 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL1683532 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1683527 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL1683534 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL1683524 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1683537 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL1683526 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL1683535 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL1683542 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL1683540 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL1683533 | — | IC50 | = | 10.57 | nM | 7.98 |
| CHEMBL1683536 | — | IC50 | = | 17.55 | nM | 7.76 |
| CHEMBL1683590 | ERIBULIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1683531 | — | IC50 | - | — | - | |
| CHEMBL1683541 | — | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - | |
| CHEMBL159 | VINBLASTINE | IC50 | - | — | - |