Assay Detail
Functional
CHEMBL1687607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT15 cells assessed as growth inhibition
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.95 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1683529 | — | — | 1 | 9.70 |
| CHEMBL1683523 | — | — | 1 | 9.68 |
| CHEMBL1683522 | — | — | 1 | 9.66 |
| CHEMBL1683528 | — | — | 1 | 9.66 |
| CHEMBL1683530 | — | — | 1 | 9.64 |
| CHEMBL1683543 | — | — | 1 | 9.62 |
| CHEMBL1683525 | — | — | 1 | 9.49 |
| CHEMBL1683539 | — | — | 1 | 9.40 |
| CHEMBL1683538 | — | — | 1 | 9.40 |
| CHEMBL1683537 | — | — | 1 | 9.36 |
| CHEMBL1683534 | — | — | 1 | 9.32 |
| CHEMBL1683524 | — | — | 1 | 9.26 |
| CHEMBL1683535 | — | — | 1 | 9.21 |
| CHEMBL1683532 | — | — | 1 | 9.21 |
| CHEMBL1683527 | — | — | 1 | 9.17 |
| CHEMBL1683542 | — | — | 1 | 9.17 |
| CHEMBL1683540 | — | — | 1 | 9.08 |
| CHEMBL1683526 | — | — | 1 | 8.91 |
| CHEMBL1683533 | — | — | 1 | 8.15 |
| CHEMBL1683536 | — | — | 1 | 7.74 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.54 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.81 |
| CHEMBL1683590 | ERIBULIN | 4.0 | 1 | 6.69 |
| CHEMBL1683531 | — | — | 1 | - |
| CHEMBL1683541 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1683529 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1683523 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1683522 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL1683528 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL1683530 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL1683543 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1683525 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1683539 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1683538 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1683537 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL1683534 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL1683524 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL1683535 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL1683532 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL1683527 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1683542 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL1683540 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL1683526 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL1683533 | — | IC50 | = | 7.08 | nM | 8.15 |
| CHEMBL1683536 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 153.95 | nM | 6.81 |
| CHEMBL1683590 | ERIBULIN | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL1683531 | — | IC50 | - | — | - | |
| CHEMBL1683541 | — | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |