Assay Detail

CHEMBL1690086

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Functional

Antiviral activity against HIV1 NL4-3 harboring reverse transcriptase K103N mutant infected in human HeLaP4 cells assessed as inhibition of viral replication after 5 days by beta-galactosidase reporter assay

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	HeLaP4
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

Corbau R, Mori J, Phillips C, Fishburn L, Martin A, Mowbray C, Panton W, Smith-Burchnell C, Thornberry A, Ringrose H, Knöchel T, Irving S, Westby M, Wood A, Perros M.
Antimicrob Agents Chemother (2010) 54 : 4451 -4463
PubMed 20660667 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.15	8.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL571987	LERSIVIRINE	2.0	1	8.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL571987	LERSIVIRINE	EC50	=	7.05	nM	8.15