Assay Detail

CHEMBL1690209

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Functional

Antiviral activity against HIV1 NL4-3 infected in human MT2 cells assessed as inhibition of virus-induced cell death at 0.5 multiplicities of infection after 6 days

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	MT2
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

Corbau R, Mori J, Phillips C, Fishburn L, Martin A, Mowbray C, Panton W, Smith-Burchnell C, Thornberry A, Ringrose H, Knöchel T, Irving S, Westby M, Wood A, Perros M.
Antimicrob Agents Chemother (2010) 54 : 4451 -4463
PubMed 20660667 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	5	9.30	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404519	BEVIRIMAT	2.0	1	9.30
CHEMBL5483011	INDINAVIR	3.0	1	9.30
CHEMBL308954	ETRAVIRINE	4.0	1	9.30
CHEMBL223228	EFAVIRENZ	4.0	1	9.30
CHEMBL571987	LERSIVIRINE	2.0	1	9.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404519	BEVIRIMAT	EC50	=	0.5	nM	9.30
CHEMBL5483011	INDINAVIR	EC50	=	0.5	nM	9.30
CHEMBL308954	ETRAVIRINE	EC50	=	0.5	nM	9.30
CHEMBL223228	EFAVIRENZ	EC50	=	0.5	nM	9.30
CHEMBL571987	LERSIVIRINE	EC50	=	0.5	nM	9.30