Assay Detail
Binding
CHEMBL1692770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Telomerase activity in cell free system by TRAP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.17 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443683 | TELOMESTATIN | — | 1 | 9.15 |
| CHEMBL1689442 | — | — | 1 | 5.52 |
| CHEMBL1689438 | — | — | 1 | 5.00 |
| CHEMBL1689441 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443683 | TELOMESTATIN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1689442 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1689438 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1689441 | — | IC50 | = | 10000.0 | nM | 5.00 |