Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL443683

TELOMESTATIN
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1oc2nc1-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)C1=NC(CS1)c1nc-2c(C)o1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL443683
Name TELOMESTATIN
Phase Preclinical
Structure Type MOL
InChI Key YVSQVYZBDXIXCC-UHFFFAOYSA-N
2
Targets
10
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

582.5
MW (Da)
5.77
ALogP
16
HBA
0
HBD
194.6
PSA (Ų)
0.21
QED
3
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H14N8O7S
MW 582.51
Aromatic Rings 7
Heavy Atoms 42
NP-Likeness 0.11

Activity Summary

IC50 10 meas. best 9.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Telomerase reverse transcriptase
CHEMBL2916
 IC50 9.19 7.7743 0.6 7
Unchecked
CHEMBL612545
 IC50 5.05 5.0167 9000.0 3

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Telomerase reverse transcriptase IC50 = 0.64 nM 9.19 Inhibition of human telomerase expressed in HEK293T cells treated before telomer... 17954919
Telomerase reverse transcriptase IC50 = 0.7 nM 9.15 Inhibition of human telomerase expressed in HEK293T cells treated after telomera... 17954919
Telomerase reverse transcriptase IC50 = 0.7 nM 9.15 Inhibition of human Telomerase activity in cell free system by TRAP assay 21280624
Telomerase reverse transcriptase IC50 = 20.0 nM 7.7 Inhibition of telomerase (unknown origin) by TRAP assay -
Telomerase reverse transcriptase IC50 = 58.0 nM 7.24 Inhibition of human telomerase expressed in in HEK293T cells in presence of prim... 17954919
Telomerase reverse transcriptase IC50 = 900.0 nM 6.05 Inhibition of human telomerase expressed in HEK293T cells in presence of primer ... 17954919
Telomerase reverse transcriptase IC50 = 1150.0 nM 5.94 Inhibition of human telomerase expressed in HEK293T cells in presence of primer ... 17954919
Unchecked IC50 = 9000.0 nM 5.05 Binding affinity to Homo sapiens (human) G-quadruplex DNA assessed as formation ... -
Unchecked IC50 = 10000.0 nM 5.0 Binding affinity to Homo sapiens (human) G-quadruplex DNA assessed as formation ... -
Unchecked IC50 = 10000.0 nM 5.0 Binding affinity to Homo sapiens (human) G-quadruplex DNA assessed as formation ... -

Literature References

PubMed DOI Target Context # Activities
17954919 10.1073/pnas.0707365104 Telomerase reverse transcriptase 7
- 10.1007/s00044-009-9233-5 Unchecked 3
19473838 10.1016/j.bmcl.2009.05.025 Nucleic Acid 2
21280624 10.1021/jm1013665 Telomerase reverse transcriptase 1
- 10.1007/s00044-011-9594-4 Telomerase reverse transcriptase 1
- 10.1039/C0MD00241K Telomerase reverse transcriptase 1
24947479 10.1016/j.bmc.2014.05.030 U2OS 1

Data from ChEMBL 36 via Core Engine