Assay Detail
Binding
CHEMBL926068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.78 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443683 | TELOMESTATIN | — | 1 | 9.19 |
| CHEMBL259739 | — | — | 1 | 8.82 |
| CHEMBL336434 | — | — | 1 | 7.35 |
| CHEMBL409247 | — | — | 1 | 7.28 |
| CHEMBL65606 | TMPYP4 | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443683 | TELOMESTATIN | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL259739 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL336434 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL409247 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL65606 | TMPYP4 | IC50 | = | 550.0 | nM | 6.26 |