Assay Detail
Binding
CHEMBL926072
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Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.26 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409247 | — | — | 1 | 7.35 |
| CHEMBL443683 | TELOMESTATIN | — | 1 | 7.24 |
| CHEMBL259739 | — | — | 1 | 7.20 |
| CHEMBL336434 | — | — | 1 | - |
| CHEMBL65606 | TMPYP4 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409247 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL443683 | TELOMESTATIN | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL259739 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL336434 | — | IC50 | - | — | - | |
| CHEMBL65606 | TMPYP4 | IC50 | - | — | - |