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Assay Detail

CHEMBL3391067

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of telomerase (unknown origin) by TRAP assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Telomerase reverse transcriptase (CHEMBL2916)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Natural products targeting telomere maintenance
Chen JL, Sperry J, Ip NY, Brimble MA
Medchemcomm (2011) 2 : 229 -245
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.29 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3347538 1 8.30
CHEMBL3347541 1 7.70
CHEMBL3347540 1 7.70
CHEMBL398742 1 7.70
CHEMBL3347539 1 7.70
CHEMBL443683 TELOMESTATIN 1 7.70
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 6.00
CHEMBL3347523 1 5.50
CHEMBL340160 ASCIDIDEMIN 1 -
CHEMBL327101 MERIDINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3347538 IC50 = 5.0 nM 8.30
CHEMBL3347541 IC50 = 20.0 nM 7.70
CHEMBL3347540 IC50 = 20.0 nM 7.70
CHEMBL398742 IC50 = 20.0 nM 7.70
CHEMBL3347539 IC50 = 20.0 nM 7.70
CHEMBL443683 TELOMESTATIN IC50 = 20.0 nM 7.70
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 1000.0 nM 6.00
CHEMBL3347523 IC50 = 3200.0 nM 5.50
CHEMBL340160 ASCIDIDEMIN IC50 > 80.0 ug.mL-1 -
CHEMBL327101 MERIDINE IC50 = 11.0 ug.mL-1 -