Assay Detail
Functional
CHEMBL1692828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 3B harboring integrase T124A mutant gene infected in human MT2 cells assessed as inhibition of virus induced cytopathic effect selected after 14 passages measured after 2 to 3 days by PCR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.59 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213165 | DOLUTEGRAVIR SODIUM | 4.0 | 1 | 9.59 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | 4.0 | 1 | 9.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213165 | DOLUTEGRAVIR SODIUM | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL518520 | RALTEGRAVIR POTASSIUM | EC50 | = | 0.26 | nM | 9.59 |