Assay Detail

CHEMBL1692966

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Functional

Antiviral activity against Human immunodeficiency virus 1 3B harboring integrase T124A,Q148K,Q148R,E138K/Q148K,E138K/Q148R,G140S/Q148R,V151I/N155H,N155H/I204T,N17S/Q148K/G163R,T124A/V151I/N155H,E138K/Q148K/G163R,G140C/Q148K/G163R,E92Q/E138K/Q148K/M154I mutant infected in human MT2 cells assessed as inhibition of virus-induced effect selected on day 84 after 24 passages by PCR

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	MT2
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.

Kobayashi M, Yoshinaga T, Seki T, Wakasa-Morimoto C, Brown KW, Ferris R, Foster SA, Hazen RJ, Miki S, Suyama-Kagitani A, Kawauchi-Miki S, Taishi T, Kawasuji T, Johns BA, Underwood MR, Garvey EP, Sato A, Fujiwara T.
Antimicrob Agents Chemother (2011) 55 : 813 -821
PubMed 21115794 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.50	7.50

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL518520	RALTEGRAVIR POTASSIUM	4.0	1	7.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL518520	RALTEGRAVIR POTASSIUM	EC50	=	32.0	nM	7.50