Assay Detail
Functional
CHEMBL1693136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688857 | — | — | 2 | 8.15 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.89 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 7.82 |
| CHEMBL1688855 | — | — | 2 | 7.75 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.35 |
| CHEMBL1688854 | — | — | 1 | 5.52 |
| CHEMBL1688856 | — | — | 1 | 5.34 |
| CHEMBL1688858 | — | — | 1 | 5.11 |
| CHEMBL1688859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688857 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1688857 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1688855 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1688855 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1688854 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1688856 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1688858 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1688859 | — | IC50 | > | 10000.0 | nM | - |