Assay Detail
Functional
CHEMBL1693137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.73 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.92 |
| CHEMBL1688857 | — | — | 1 | 7.62 |
| CHEMBL1688855 | — | — | 1 | 7.37 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1688857 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1688855 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 45.0 | nM | 7.35 |