Assay Detail
Functional
CHEMBL1693333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse MEF cells expressing mcl-1 fl/fl after 24 hrs by Cell titer glo assay in presence of 10% serum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MEF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.29 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1689143 | — | — | 1 | 5.37 |
| CHEMBL1689145 | — | — | 1 | 5.26 |
| CHEMBL1689139 | — | — | 1 | 5.24 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
| CHEMBL1689146 | — | — | 1 | - |
| CHEMBL1689144 | — | — | 1 | - |
| CHEMBL1689142 | — | — | 1 | - |
| CHEMBL1689141 | — | — | 1 | - |
| CHEMBL1689140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1689143 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1689145 | — | EC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL1689139 | — | EC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL376408 | ABT 737 | EC50 | > | 10000.0 | nM | - |
| CHEMBL1689146 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1689144 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1689142 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1689141 | — | EC50 | - | — | - | |
| CHEMBL1689140 | — | EC50 | > | 10000.0 | nM | - |