Assay Detail
Functional
CHEMBL1693335
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Cytotoxicity against human NCI-H146 after 48 hrs by MTS assay in presence of 10% human serum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H146 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.16 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.10 |
| CHEMBL1689143 | — | — | 1 | 6.27 |
| CHEMBL1689139 | — | — | 1 | 6.21 |
| CHEMBL1689142 | — | — | 1 | 6.20 |
| CHEMBL1689145 | — | — | 1 | 6.15 |
| CHEMBL1689146 | — | — | 1 | 5.96 |
| CHEMBL1689144 | — | — | 1 | 5.92 |
| CHEMBL1689140 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1689143 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1689139 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1689142 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1689145 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1689146 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1689144 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1689140 | — | EC50 | = | 3700.0 | nM | 5.43 |