Assay Detail
Functional
CHEMBL1693648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3.Luc in human PBMC assessed as infectivity treated for 24 hrs by luciferase assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.22 | 9.52 |
| EC95 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 2 | 9.52 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 2 | 8.62 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 2 | 7.39 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 2 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL254316 | RALTEGRAVIR | EC95 | = | 0.048 | uM | - |
| CHEMBL204656 | ELVITEGRAVIR | EC95 | = | 0.0074 | uM | - |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC95 | = | 0.72 | uM | - |
| CHEMBL57 | NEVIRAPINE | EC95 | = | 0.69 | uM | - |