Assay Detail
Binding
CHEMBL1693939
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Displacement of [3H]-paroxetine from SERT in rabbit cortical membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.40 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 9.51 |
| CHEMBL153036 | R-FLUOXETINE | — | 1 | 8.24 |
| CHEMBL1689299 | — | — | 1 | 7.99 |
| CHEMBL1689295 | — | — | 1 | 7.65 |
| CHEMBL1689291 | — | — | 1 | 7.54 |
| CHEMBL1689296 | — | — | 1 | 7.09 |
| CHEMBL1689293 | — | — | 1 | 7.01 |
| CHEMBL1689297 | — | — | 1 | 7.01 |
| CHEMBL1689300 | — | — | 1 | 7.01 |
| CHEMBL1689294 | — | — | 1 | 6.86 |
| CHEMBL1689292 | — | — | 1 | 6.51 |
| CHEMBL1689298 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL153036 | R-FLUOXETINE | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1689299 | — | Ki | = | 10.28 | nM | 7.99 |
| CHEMBL1689295 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL1689291 | — | Ki | = | 28.74 | nM | 7.54 |
| CHEMBL1689296 | — | Ki | = | 81.07 | nM | 7.09 |
| CHEMBL1689293 | — | Ki | = | 98.42 | nM | 7.01 |
| CHEMBL1689297 | — | Ki | = | 96.82 | nM | 7.01 |
| CHEMBL1689300 | — | Ki | = | 96.58 | nM | 7.01 |
| CHEMBL1689294 | — | Ki | = | 138.61 | nM | 6.86 |
| CHEMBL1689292 | — | Ki | = | 305.9 | nM | 6.51 |
| CHEMBL1689298 | — | Ki | = | 396.5 | nM | 6.40 |