Assay Detail
Functional
CHEMBL1694199
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Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.55 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.04 |
| CHEMBL1630 | — | — | 1 | 8.30 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.20 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.97 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.52 |
| CHEMBL221655 | — | — | 1 | 6.58 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.52 |
| CHEMBL220692 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL1630 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL221655 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL220692 | — | IC50 | = | 533.0 | nM | 6.27 |