Assay Detail
Binding
CHEMBL1695103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) (CHEMBL5767) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.46 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.00 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.68 |
| CHEMBL606453 | — | — | 1 | 6.07 |
| CHEMBL589604 | — | — | 1 | 6.05 |
| CHEMBL517222 | ENDIANDRIN B | — | 1 | 6.05 |
| CHEMBL589606 | — | — | 1 | 6.04 |
| CHEMBL603189 | POLYANDROCARPAMINE A | — | 1 | 6.04 |
| CHEMBL591736 | POLYANDROCARPAMINE B | — | 1 | 6.04 |
| CHEMBL601464 | — | — | 1 | 6.01 |
| CHEMBL589354 | — | — | 1 | 6.01 |
| CHEMBL588491 | — | — | 1 | 5.94 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.52 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.15 |
| CHEMBL228274 | ENDIANDRIN A | — | 1 | 5.05 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 5.04 |
| CHEMBL447310 | — | — | 1 | 5.04 |
| CHEMBL578932 | — | — | 1 | 4.99 |
| CHEMBL605189 | — | — | 1 | 4.98 |
| CHEMBL592010 | — | — | 1 | 4.97 |
| CHEMBL590883 | — | — | 1 | 4.96 |
| CHEMBL463134 | (+)-XYLARIAMIDE A | — | 1 | 4.96 |
| CHEMBL463133 | (-)-XYLARIAMIDE A | — | 1 | 4.95 |
| CHEMBL592140 | — | — | 1 | 4.95 |
| CHEMBL1772 | — | — | 1 | 4.94 |
| CHEMBL592384 | — | — | 1 | 4.94 |
| CHEMBL53566 | TYROSOL | — | 1 | 4.92 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL606453 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL589604 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL517222 | ENDIANDRIN B | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL589606 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL603189 | POLYANDROCARPAMINE A | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL591736 | POLYANDROCARPAMINE B | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL601464 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL589354 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL588491 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 7110.0 | nM | 5.15 |
| CHEMBL228274 | ENDIANDRIN A | Ki | = | 8920.0 | nM | 5.05 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL447310 | — | Ki | = | 9120.0 | nM | 5.04 |
| CHEMBL578932 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL605189 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL592010 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL590883 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL463134 | (+)-XYLARIAMIDE A | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL463133 | (-)-XYLARIAMIDE A | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL592140 | — | Ki | = | 11200.0 | nM | 4.95 |
| CHEMBL1772 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL592384 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL53566 | TYROSOL | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL14060 | PHENOL | Ki | = | 79000.0 | nM | 4.10 |