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Assay Detail

CHEMBL1695105

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Carbonic anhydrase (CHEMBL5337)
Type SINGLE PROTEIN
Organism Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Publication

Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.
Davis RA, Hofmann A, Osman A, Hall RA, Mühlschlegel FA, Vullo D, Innocenti A, Supuran CT, Poulsen SA.
J Med Chem (2011) 54 : 1682 -1692
PubMed 21332115 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 5.99 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.89
CHEMBL375927 (-)-DIHYDROGUAIARETICACID 1 6.21
CHEMBL517222 ENDIANDRIN B 1 6.16
CHEMBL589606 1 6.14
CHEMBL228274 ENDIANDRIN A 1 6.14
CHEMBL589604 1 6.12
CHEMBL589354 1 6.11
CHEMBL606453 1 6.10
CHEMBL605189 1 6.09
CHEMBL591736 POLYANDROCARPAMINE B 1 6.05
CHEMBL447310 1 6.04
CHEMBL603189 POLYANDROCARPAMINE A 1 6.04
CHEMBL601464 1 6.03
CHEMBL750 ZONISAMIDE 4.0 1 6.03
CHEMBL578932 1 6.02
CHEMBL590883 1 6.00
CHEMBL588491 1 6.00
CHEMBL592140 1 6.00
CHEMBL1772 1 5.99
CHEMBL463133 (-)-XYLARIAMIDE A 1 5.99
CHEMBL592384 1 5.97
CHEMBL463134 (+)-XYLARIAMIDE A 1 5.97
CHEMBL592010 1 5.97
CHEMBL220492 TOPIRAMATE 4.0 1 5.96
CHEMBL53566 TYROSOL 1 5.96
CHEMBL21 SULFANILAMIDE 4.0 1 5.12
CHEMBL14060 PHENOL 4.0 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 130.0 nM 6.89
CHEMBL375927 (-)-DIHYDROGUAIARETICACID Ki = 620.0 nM 6.21
CHEMBL517222 ENDIANDRIN B Ki = 700.0 nM 6.16
CHEMBL589606 Ki = 720.0 nM 6.14
CHEMBL228274 ENDIANDRIN A Ki = 730.0 nM 6.14
CHEMBL589604 Ki = 750.0 nM 6.12
CHEMBL589354 Ki = 780.0 nM 6.11
CHEMBL606453 Ki = 790.0 nM 6.10
CHEMBL605189 Ki = 810.0 nM 6.09
CHEMBL591736 POLYANDROCARPAMINE B Ki = 900.0 nM 6.05
CHEMBL447310 Ki = 910.0 nM 6.04
CHEMBL603189 POLYANDROCARPAMINE A Ki = 920.0 nM 6.04
CHEMBL601464 Ki = 930.0 nM 6.03
CHEMBL750 ZONISAMIDE Ki = 940.0 nM 6.03
CHEMBL578932 Ki = 960.0 nM 6.02
CHEMBL590883 Ki = 1010.0 nM 6.00
CHEMBL588491 Ki = 990.0 nM 6.00
CHEMBL592140 Ki = 1000.0 nM 6.00
CHEMBL1772 Ki = 1020.0 nM 5.99
CHEMBL463133 (-)-XYLARIAMIDE A Ki = 1030.0 nM 5.99
CHEMBL592384 Ki = 1060.0 nM 5.97
CHEMBL463134 (+)-XYLARIAMIDE A Ki = 1060.0 nM 5.97
CHEMBL592010 Ki = 1080.0 nM 5.97
CHEMBL220492 TOPIRAMATE Ki = 1110.0 nM 5.96
CHEMBL53566 TYROSOL Ki = 1100.0 nM 5.96
CHEMBL21 SULFANILAMIDE Ki = 7630.0 nM 5.12
CHEMBL14060 PHENOL Ki = 17300.0 nM 4.76