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Assay Detail

CHEMBL1695121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Varicella zoster virus YS infected in HEL cells assessed as reduction in virus induced cytopathicity
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Cell Type HEL
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues.
Diez-Torrubia A, Balzarini J, Andrei G, Snoeck R, De Meester I, Camarasa MJ, Velázquez S.
J Med Chem (2011) 54 : 1927 -1942
PubMed 21332170 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 7.62 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1688783 1 8.52
CHEMBL344738 CF1743 1 8.40
CHEMBL1688781 1 8.22
CHEMBL1688782 1 8.00
CHEMBL1688780 1 7.80
CHEMBL1688785 1 7.66
CHEMBL1688786 1 7.14
CHEMBL1688784 1 7.07
CHEMBL1688778 1 6.81
CHEMBL1688779 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1688783 EC50 = 3.0 nM 8.52
CHEMBL344738 CF1743 EC50 = 4.0 nM 8.40
CHEMBL1688781 EC50 = 6.0 nM 8.22
CHEMBL1688782 EC50 = 10.0 nM 8.00
CHEMBL1688780 EC50 = 16.0 nM 7.80
CHEMBL1688785 EC50 = 22.0 nM 7.66
CHEMBL1688786 EC50 = 73.0 nM 7.14
CHEMBL1688784 EC50 = 85.0 nM 7.07
CHEMBL1688778 EC50 = 154.0 nM 6.81
CHEMBL1688779 EC50 = 260.0 nM 6.58