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Assay Detail

CHEMBL1695275

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine tubulin polymerization after 30 mins by turbidity assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
Chekler EL, Kiselyov AS, Ouyang X, Chen X, Pattaropong V, Wang Y, Tuma MC, Doody JF.
ACS Med Chem Lett (2010) 1 : 488 -492
PubMed 24900236 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.84 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1688357 1 7.16
CHEMBL204754 1 6.30
CHEMBL203062 1 6.16
CHEMBL1087349 1 6.16
CHEMBL203642 1 6.15
CHEMBL204710 1 6.00
CHEMBL1087218 1 5.96
CHEMBL1688351 1 5.90
CHEMBL1688352 1 5.84
CHEMBL1688350 1 5.82
CHEMBL381122 1 5.77
CHEMBL1688346 1 5.77
CHEMBL205166 1 5.72
CHEMBL1688345 1 5.60
CHEMBL1688344 1 5.41
CHEMBL1688250 1 5.18
CHEMBL1688353 1 5.09
CHEMBL382359 1 5.06
CHEMBL1688247 1 -
CHEMBL1688356 1 -
CHEMBL1688355 1 -
CHEMBL1688354 1 -
CHEMBL1688349 1 -
CHEMBL1688348 1 -
CHEMBL1688249 1 -
CHEMBL1688246 1 -
CHEMBL1688248 1 -
CHEMBL1688347 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1688357 IC50 = 70.0 nM 7.16
CHEMBL204754 IC50 = 500.0 nM 6.30
CHEMBL203062 IC50 = 700.0 nM 6.16
CHEMBL1087349 IC50 = 690.0 nM 6.16
CHEMBL203642 IC50 = 710.0 nM 6.15
CHEMBL204710 IC50 = 1000.0 nM 6.00
CHEMBL1087218 IC50 = 1090.0 nM 5.96
CHEMBL1688351 IC50 = 1250.0 nM 5.90
CHEMBL1688352 IC50 = 1450.0 nM 5.84
CHEMBL1688350 IC50 = 1500.0 nM 5.82
CHEMBL381122 IC50 = 1700.0 nM 5.77
CHEMBL1688346 IC50 = 1700.0 nM 5.77
CHEMBL205166 IC50 = 1900.0 nM 5.72
CHEMBL1688345 IC50 = 2500.0 nM 5.60
CHEMBL1688344 IC50 = 3900.0 nM 5.41
CHEMBL1688250 IC50 = 6600.0 nM 5.18
CHEMBL1688353 IC50 = 8100.0 nM 5.09
CHEMBL382359 IC50 = 8800.0 nM 5.06
CHEMBL1688247 IC50 > 10000.0 nM -
CHEMBL1688356 IC50 > 10000.0 nM -
CHEMBL1688355 IC50 > 10000.0 nM -
CHEMBL1688354 IC50 > 10000.0 nM -
CHEMBL1688349 IC50 > 10000.0 nM -
CHEMBL1688348 IC50 > 10000.0 nM -
CHEMBL1688249 IC50 > 10000.0 nM -
CHEMBL1688246 IC50 > 10000.0 nM -
CHEMBL1688248 IC50 > 10000.0 nM -
CHEMBL1688347 IC50 > 10000.0 nM -