Assay Detail
Functional
CHEMBL1696370
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Antiviral activity against HIV1 infected in TNFalpha-stimulated human U1 cells assessed as inhibition of viral replication after 72 hrs
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.05 | 9.40 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688537 | — | — | 2 | 9.40 |
| CHEMBL1688540 | TEMACRAZINE | — | 1 | 8.70 |
| CHEMBL226970 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688537 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1688540 | TEMACRAZINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1688537 | — | Activity | - | — | - | |
| CHEMBL226970 | — | Activity | - | — | - | |
| CHEMBL226970 | — | EC50 | < | 0.25 | nM | - |