Assay Detail
Functional
CHEMBL1696384
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Antiviral activity against HIV1 Brazilian isolate 93BR021 infected in PHA-stimulated human PBMC assessed as inhibition of viral replication after 7 days
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.12 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688537 | — | — | 1 | 6.54 |
| CHEMBL226970 | — | — | 1 | 6.20 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688537 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL226970 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2470.0 | nM | 5.61 |