Assay Detail
Functional
CHEMBL1696451
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Inhibition of de novo lipogenesis in mouse hepatocytes assessed as 14C-acetic acid incorporation treated 1 hr before substrate administration and measured after 1 hr by scintillation counter
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.92 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688236 | — | — | 1 | 8.10 |
| CHEMBL1688231 | — | — | 1 | 7.89 |
| CHEMBL1688234 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688236 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1688231 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1688234 | — | EC50 | = | 17.0 | nM | 7.77 |