Assay Detail

CHEMBL1696706

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Functional

Antiviral activity against APV, ATV, LPV, IDV, NFV, RTV, SQV-resistant HIV-1 1064-52 infected in human PBMC assessed as inhibition of viral replication by ELISA

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.

Ptak RG, Gallay PA, Jochmans D, Halestrap AP, Ruegg UT, Pallansch LA, Bobardt MD, de Béthune MP, Neyts J, De Clercq E, Dumont JM, Scalfaro P, Besseghir K, Wenger RM, Rosenwirth B.
Antimicrob Agents Chemother (2008) 52 : 1302 -1317
PubMed 18212100 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.15	8.15

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1651956	ALISPORIVIR	3.0	1	8.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1651956	ALISPORIVIR	IC50	=	7.0	nM	8.15