Assay Detail
Functional
CHEMBL1696709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against APV, ATV, IDV, LPV, NFV, RTV, SQV, 3TC, FTC, ABC, AZT, d4T, ddC, ddI, TDF, EFV, DLV, NVP-resistant HIV-1 MDR769 infected in human PBMC assessed as inhibition of viral replication by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | IC50 | = | 12.0 | nM | 7.92 |