Assay Detail
Functional
CHEMBL1697615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 BaL infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.32 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688243 | INCB-9471 | 2.0 | 1 | 9.80 |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | 9.64 |
| CHEMBL1688242 | — | — | 1 | 7.96 |
| CHEMBL1688240 | — | — | 1 | 7.72 |
| CHEMBL1688239 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688243 | INCB-9471 | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL82301 | VICRIVIROC | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL1688242 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1688240 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1688239 | — | IC50 | = | 334.0 | nM | 6.48 |