Assay Detail
Functional
CHEMBL1737987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: SAR Analysis for the identification of Selective Antagonists of ERK1/2 Activity in GPR35-Overexpressing U2OS Cells - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2058, AID2079]
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1708510 | — | — | 1 | 5.86 |
| CHEMBL1700467 | — | — | 1 | 5.77 |
| CHEMBL1716874 | — | — | 1 | 5.64 |
| CHEMBL1723578 | — | — | 1 | 5.39 |
| CHEMBL1709632 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1708510 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL1700467 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL1716874 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL1723578 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL1709632 | — | IC50 | = | 21800.0 | nM | 4.66 |