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Evidence Snapshot

G-protein coupled receptor 35

CHEMBL1293267 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:06:39Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1293267
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled receptor 35 as ChEMBL target CHEMBL1293267, mapped to UniProt Q9HC97. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled receptor 35
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1293267
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9HC97
G-protein coupled receptor 35
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why G-protein coupled receptor 35 matters

As of 2026-09-14

G-protein coupled receptor 35 is reviewed as G-protein coupled receptor 35 (UniProt Q9HC97); the current evidence base includes 20 approved drugs, 1042 compounds, and 162 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 20 approved drugs, 1042 compounds, and 162 assays for this target. The dominant activity type is EC50. CHEMBL4857772 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL4857772 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
20 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why G-protein coupled receptor 35 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9HC97, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1042
Total Compounds
162
Total Assays
20
Approved Drugs
IC50: 534.0, KI: 74.0, EC50: 715.0, KD: 8.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4857772
 9.5 EC50 —
No preferred name
CHEMBL4857772
 9.3 IC50 —
No preferred name
CHEMBL2425821
 9.2 Ki —
No preferred name
CHEMBL28079
 9.2 EC50 Clinical
No preferred name
CHEMBL3306990
 9.1 IC50 —

Approved Drugs

Structure Compound First Approval
LODOXAMIDE
CHEMBL1201266
 1993
CROMOLYN
CHEMBL428880
 1982
LOPERAMIDE HYDROCHLORIDE
CHEMBL1707
 1976
DICUMAROL
CHEMBL1466
 1944
EMETINE
CHEMBL50588
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:06:39Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1293267