Compound Detail
CHEMBL1201266
LODOXAMIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1201266 |
| Name | LODOXAMIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | RVGLGHVJXCETIO-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
13
Publications
2
Known Names
1
Indications
Molecular Properties
311.6
MW (Da)
0.26
ALogP
5
HBA
4
HBD
156.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1993 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Eye Manifestations
ATC Classification
S01GX05
lodoxamide
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
EC50 6 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 7.89 | 7.78 | 13.0 | 2 |
| G-protein coupled receptor 35 CHEMBL1293267 | EC50 | 7.39 | 6.395 | 41.1 | 2 |
| G-protein coupled receptor 35 CHEMBL2390813 | EC50 | 6.38 | 6.38 | 422.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 13.0 | nM | 7.89 | Agonist activity at rat GPR35 by beta-arrestin recruitment assay | 37976806 |
| Unchecked | EC50 | = | 21.5 | nM | 7.67 | Agonist activity at rat GPR35 expressed in HEK293 cells co-expressing Galpha16 a... | 37976806 |
| G-protein coupled receptor 35 | EC50 | = | 41.1 | nM | 7.39 | Agonist activity at human GPR35 expressed in HEK293 cells co-expressing Galpha16... | 37976806 |
| G-protein coupled receptor 35 | EC50 | = | 422.0 | nM | 6.38 | Agonist activity at mouse GPR35 expressed in HEK293 cells co-expressing Galpha16... | 37976806 |
| G-protein coupled receptor 35 | EC50 | = | 4000.0 | nM | 5.4 | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-... | 27976894 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16472241 | 10.2174/1570163043334794 | Hepatotoxicity | 18 |
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 37976806 | 10.1016/j.bmc.2023.117511 | G-protein coupled receptor 35 | 5 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| 102796 | 10.1021/jm00207a016 | Rattus norvegicus | 3 |
| 37976806 | 10.1016/j.bmc.2023.117511 | Unchecked | 3 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 27976894 | 10.1021/acs.jmedchem.6b01431 | G-protein coupled receptor 35 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine