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Target Snapshot

CHEMBL2390813 Target Snapshot

G-protein coupled receptor 35 · SINGLE PROTEIN · Mus musculus

67Compounds
6Assays
3Approved Drugs
34.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9ES90. Use UniProt Q9ES90 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9ES90 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled receptor 35 as ChEMBL target CHEMBL2390813, mapped to UniProt Q9ES90. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled receptor 35
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2390813
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9ES90
G-protein coupled receptor 35
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether G-protein coupled receptor 35 is the right protein anchor across sources, using UniProt Q9ES90 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG-protein coupled receptor 35
UniProt AccessionQ9ES90
Component TypeProtein
Sequence Length307 aa

G-protein coupled receptor 35

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as G-protein coupled receptor 35, mapped to UniProt Q9ES90. Sequence length is 307 aa.

Mapped IDQ9ES90
Review nameG-protein coupled receptor 35
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
Assay Mix

Activity Type Distribution

EC5034.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5416593 7.91 EC50 12.4 Preclinical
CHEMBL5423540 7.68 EC50 20.9 Preclinical
CHEMBL5437161 7.57 EC50 27.2 Preclinical
CHEMBL5430512 7.55 EC50 28.1 Preclinical
CHEMBL5415083 7.37 EC50 42.5 Preclinical
CHEMBL3245052 7.25 EC50 55.8 Preclinical
CHEMBL5422437 7.21 EC50 61.0 Preclinical
CHEMBL3245030 7.2 EC50 63.7 Preclinical
CHEMBL3245049 7.16 EC50 69.1 Preclinical
CHEMBL5399225 7.02 EC50 94.7 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
2
5.5
4
6.0
3
6.5
6
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LODOXAMIDE
CHEMBL1201266
Approved 1993
Assay Landscape

Assay Landscape

6
Total Assays
24
Tested Compounds
2
Assay Types
Binding — 3 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 9 5.3
Functional — 3 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 21 6.6
assay format 1 3 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine