Assay Detail
Binding
CHEMBL5330770
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Agonist activity at rat GPR35 expressed in HEK293 cells co-expressing Galpha16 assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.18 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201266 | LODOXAMIDE | 4.0 | 1 | 7.67 |
| CHEMBL5430512 | — | — | 1 | 7.46 |
| CHEMBL5437161 | — | — | 1 | 7.24 |
| CHEMBL5415083 | — | — | 1 | 7.20 |
| CHEMBL5423540 | — | — | 1 | 7.19 |
| CHEMBL3245052 | — | — | 1 | 7.12 |
| CHEMBL3245030 | — | — | 1 | 7.11 |
| CHEMBL3245049 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201266 | LODOXAMIDE | EC50 | = | 21.5 | nM | 7.67 |
| CHEMBL5430512 | — | EC50 | = | 34.6 | nM | 7.46 |
| CHEMBL5437161 | — | EC50 | = | 57.8 | nM | 7.24 |
| CHEMBL5415083 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5423540 | — | EC50 | = | 65.2 | nM | 7.19 |
| CHEMBL3245052 | — | EC50 | = | 76.7 | nM | 7.12 |
| CHEMBL3245030 | — | EC50 | = | 77.8 | nM | 7.11 |
| CHEMBL3245049 | — | EC50 | = | 383.0 | nM | 6.42 |