Assay Detail
Binding
CHEMBL5330795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GPR35 by beta-arrestin recruitment assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.54 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150764 | BUFROLIN | 2.0 | 1 | 8.00 |
| CHEMBL1201266 | LODOXAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 7.00 |
| CHEMBL2392174 | — | — | 1 | 5.85 |
| CHEMBL428880 | CROMOLYN | 4.0 | 1 | 5.40 |
| CHEMBL2392141 | — | — | 1 | 5.10 |
| CHEMBL177880 | PAMOIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150764 | BUFROLIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1201266 | LODOXAMIDE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2392174 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL428880 | CROMOLYN | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2392141 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL177880 | PAMOIC ACID | EC50 | > | 100000.0 | nM | - |