Assay Detail
Binding
CHEMBL4042612
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Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.04 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392174 | — | — | 1 | 7.92 |
| CHEMBL3277775 | — | — | 1 | 7.89 |
| CHEMBL177880 | PAMOIC ACID | — | 1 | 6.30 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 5.89 |
| CHEMBL1096 | AMLEXANOX | 4.0 | 1 | 5.40 |
| CHEMBL1201266 | LODOXAMIDE | 4.0 | 1 | 5.40 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.38 |
| CHEMBL428880 | CROMOLYN | 4.0 | 1 | 5.16 |
| CHEMBL1914576 | — | — | 1 | 4.99 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392174 | — | EC50 | = | 12.1 | nM | 7.92 |
| CHEMBL3277775 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL177880 | PAMOIC ACID | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1466 | DICUMAROL | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1096 | AMLEXANOX | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1201266 | LODOXAMIDE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL428880 | CROMOLYN | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1914576 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL299155 | TRANSTORINE | EC50 | = | 217000.0 | nM | - |