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Assay Detail

CHEMBL1738385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Unclassified
PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 3 (STAT3). (Class of assay: screening) [Related pubchem assays (depositor defined):AID1267, AID1309, AID1318, AID1398, AID1406, AID1805, AID871, AID932] Panel member name: STAT3 Activation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Unclassified
Category screening
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Signal transducer and activator of transcription 3 (CHEMBL4026)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 7.07 8.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1389016 1 8.98
CHEMBL1449962 1 8.66
CHEMBL1703740 1 8.34
CHEMBL1430610 1 8.09
CHEMBL1729988 1 5.22
CHEMBL1707774 1 5.16
CHEMBL1722282 1 5.02
CHEMBL1698563 1 -
CHEMBL1701324 1 -
CHEMBL1735352 1 -
CHEMBL1717477 1 -
CHEMBL1729319 1 -
CHEMBL1736009 1 -
CHEMBL1702219 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1389016 EC50 = 1.04 nM 8.98
CHEMBL1449962 EC50 = 2.19 nM 8.66
CHEMBL1703740 EC50 = 4.55 nM 8.34
CHEMBL1430610 EC50 = 8.15 nM 8.09
CHEMBL1729988 EC50 = 6080.0 nM 5.22
CHEMBL1707774 EC50 = 6978.0 nM 5.16
CHEMBL1722282 EC50 = 9618.0 nM 5.02
CHEMBL1698563 EC50 > 5569.0 nM -
CHEMBL1701324 EC50 > 55690.0 nM -
CHEMBL1735352 EC50 > 55690.0 nM -
CHEMBL1717477 EC50 > 55690.0 nM -
CHEMBL1729319 EC50 > 5569.0 nM -
CHEMBL1736009 EC50 > 5569.0 nM -
CHEMBL1702219 EC50 > 55690.0 nM -