Assay Detail

CHEMBL1743487

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET

Mechanism based inhibition of rabbit cytochrome P450 2B4

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Cytochrome P450 2B4 (CHEMBL1743542) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Cytochrome P450 2B4 (CHEMBL1743542) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2B4

CHEMBL1743542

Anchored from Assay target.

Protein identity Cytochrome P450 2B4

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Oryctolagus cuniculus
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Cytochrome P450 2B4 (CHEMBL1743542) ↗

Type	SINGLE PROTEIN
Organism	Oryctolagus cuniculus

Publication

Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Fontana E, Dansette PM, Poli SM.
Curr Drug Metab (2005) 6 : 413 -454
PubMed 16248836 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	5.55	5.55
Kinact	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1078442	BERGAMOTTIN	—	2	5.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1078442	BERGAMOTTIN	Ki	=	2800.0	nM	5.55
CHEMBL1078442	BERGAMOTTIN	Kinact	=	0.068	min-1	-