Assay Detail
ADMET
CHEMBL1743533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mechanism based inhibition of human cytochrome P450 1A2 measured by phenacetin O-deethylation (POD)
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.10 | 4.18 |
| Kinact | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1743359 | — | — | 2 | 4.18 |
| CHEMBL1164975 | — | — | 2 | 4.01 |
| CHEMBL93 | ZILEUTON | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1743359 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL1164975 | — | Ki | = | 98200.0 | nM | 4.01 |
| CHEMBL93 | ZILEUTON | Ki | = | 117000.0 | nM | - |
| CHEMBL93 | ZILEUTON | Kinact | = | 0.035 | min-1 | - |
| CHEMBL1743359 | — | Kinact | = | 0.012 | min-1 | - |
| CHEMBL1164975 | — | Kinact | = | 0.037 | min-1 | - |