Assay Detail
ADMET
CHEMBL1763137
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Inhibition of CYP1A2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 5.30 |
| CHEMBL1760205 | — | — | 1 | 4.68 |
| CHEMBL1760206 | — | — | 1 | 4.47 |
| CHEMBL1760200 | — | — | 1 | - |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10188 | TALNETANT | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1760205 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1760206 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1760200 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL346178 | OSANETANT | IC50 | > | 100000.0 | nM | - |