Assay Detail
ADMET
CHEMBL1763139
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Inhibition of CYP2C19
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.12 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760205 | — | — | 1 | 5.22 |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 5.16 |
| CHEMBL1760206 | — | — | 1 | 5.05 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 5.05 |
| CHEMBL1760200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760205 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL346178 | OSANETANT | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1760206 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL10188 | TALNETANT | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1760200 | — | IC50 | > | 15000.0 | nM | - |