Assay Detail
Binding
CHEMBL1763145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760332 | — | — | 1 | 7.70 |
| CHEMBL1760198 | — | — | 1 | 6.92 |
| CHEMBL1760349 | — | — | 1 | 6.72 |
| CHEMBL1760333 | — | — | 1 | 6.62 |
| CHEMBL1760204 | — | — | 1 | 6.62 |
| CHEMBL1760338 | — | — | 1 | 6.60 |
| CHEMBL1760213 | — | — | 1 | 6.58 |
| CHEMBL1760209 | — | — | 1 | 6.51 |
| CHEMBL1760207 | — | — | 1 | 6.46 |
| CHEMBL1760202 | — | — | 1 | 6.43 |
| CHEMBL1760206 | — | — | 1 | 6.43 |
| CHEMBL1760331 | — | — | 1 | 6.40 |
| CHEMBL1760339 | — | — | 1 | 6.31 |
| CHEMBL1760210 | — | — | 1 | 6.29 |
| CHEMBL1760337 | — | — | 1 | 6.28 |
| CHEMBL1760205 | — | — | 1 | 6.27 |
| CHEMBL1760212 | — | — | 1 | 6.16 |
| CHEMBL1760200 | — | — | 1 | 5.96 |
| CHEMBL1760336 | — | — | 1 | 5.80 |
| CHEMBL1306947 | — | — | 1 | 5.75 |
| CHEMBL1760335 | — | — | 1 | 5.60 |
| CHEMBL1760217 | — | — | 1 | 5.54 |
| CHEMBL1760214 | — | — | 1 | 5.44 |
| CHEMBL1760215 | — | — | 1 | - |
| CHEMBL1760208 | — | — | 1 | - |
| CHEMBL1760340 | — | — | 1 | - |
| CHEMBL1760341 | — | — | 1 | - |
| CHEMBL1760342 | — | — | 1 | - |
| CHEMBL1760343 | — | — | 1 | - |
| CHEMBL1760203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760332 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1760198 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1760349 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1760333 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1760204 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1760338 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1760213 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL1760209 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1760207 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1760202 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL1760206 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL1760331 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1760339 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL1760210 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1760337 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL1760205 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL1760212 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1760200 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1760336 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL1306947 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1760335 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1760217 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL1760214 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL1760216 | — | Ki | - | — | - | |
| CHEMBL1760334 | — | Ki | - | — | - | |
| CHEMBL1760350 | — | Ki | - | — | - | |
| CHEMBL1760218 | — | Ki | - | — | - | |
| CHEMBL1760199 | — | Ki | - | — | - | |
| CHEMBL1760348 | — | Ki | - | — | - | |
| CHEMBL1760347 | — | Ki | - | — | - | |
| CHEMBL1760211 | — | Ki | - | — | - | |
| CHEMBL1760346 | — | Ki | - | — | - | |
| CHEMBL1760345 | — | Ki | - | — | - | |
| CHEMBL1760219 | — | Ki | - | — | - | |
| CHEMBL1760215 | — | Ki | - | — | - | |
| CHEMBL1760197 | — | Ki | - | — | - | |
| CHEMBL1760201 | — | Ki | - | — | - | |
| CHEMBL1760344 | — | Ki | - | — | - | |
| CHEMBL1760203 | — | Ki | - | — | - | |
| CHEMBL1760343 | — | Ki | - | — | - | |
| CHEMBL1760342 | — | Ki | - | — | - | |
| CHEMBL1760341 | — | Ki | - | — | - | |
| CHEMBL1760340 | — | Ki | - | — | - | |
| CHEMBL1760208 | — | Ki | - | — | - |